Core IM | Internal Medicine Podcast

How much do beta blockers help after a heart attack, even when the heart’s pumping well? In this episode, we revisit the origins of beta blockers in post-MI care, examine how evidence evolved, and explore the REDUCE-AMI trial, which questions whether beta blockers are still needed for all.

Listen to this latest episode of Beyond Journal Club, a collaboration between Core IM and NEJM Group, where we put research into context tracing the arc of evidence, dissecting the clinical question, and exploring what the findings could mean for real-world patient care

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🔹 Transcript and Show Notes

Timestamps:

(00:48) | Background on Beta Blockers and Their Mechanism

(02:41) | Historical Context of Beta Blockers in Heart Disease

(04:56) | Capricorn Trial and Its Impact

(07:17) | Emergence of Doubts About Beta Blockers

(10:09) | Introduction to the REDUCED-AMI Trial

(15:52) | Discussion on Trial Interpretation and Clinical Implications

(16:18) | Comparison with Other Trials and Future Directions

Tags:  CoreIM, Internal Medicine, Primary Care, Medical Education, IMCore, Physician Assistant, Nurse Practitioner, Medical Student, Cardiology

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🔹 What is invasive fungal disease, and who is most at risk for developing invasive fungal disease? (~ 02:46)

🔹 What are the main classes of fungi? (~11:35)

🔹 What are the pros and cons of B-D Glucan and Galactomannan (~19:16)

🔹 How to increase the yield of blood cultures? How to interpret yeast growth in sputum/BAL and urine cultures? (~ 30:42)

🔹 How is invasive fungal disease treated? (~ 35:14)

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📌 Transcript & show notes

Tags: CoreIM, IMCore, Infectious Disease, Hospital Medicine, Hospitalist, ICU, Medical Education, Physician Assistant, Nurse Practitioner, Medical Student, mold

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🔹What are clinically relevant limitations of an A1c vs. a CGM (1:40)

🔹What do the different parts of the ambulatory glucose profile tell you? (09:59)

🔹What are common pitfalls, medications, lifestyle patterns that are important to ask your patient about when seeing them for a visit to manage blood sugar? (15:19)

🔹 How can you titrate insulin based on when you see the hypoglycemia on the ambulatory glucose profile (20:00)

🔹 When there is too much hyperglycemia, how do you titrate insulin when adding on GLP-1 agonists? (26:30)

📌 Sponsor:  NEJM Fellowship Program, click here to learn more and/or apply!

📌 Transcript & show notes

Tags: CoreIM, IMCore, Endocrinology, Primary Care, Medical Education, Physician Assistant, Nurse Practitioner, Medical Student, diabetes management, insulin titration

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🔹When is an U/S vs. CT vs. MRI helpful before consulting Interventional Radiology?

🔹What factors go into an IR pre-op evaluation?

🔹 When do drains go in, and when do they come out?

🔹 When a patient has trouble with a drain, what are things you can do before calling IR?

🔹 What does outpatient IR follow up entail, and what does a capping trial of PCN tubes entail?

📌  Sponsor: Oakstone CME’s ACP MKSAP Audio Companion

Use the code "CORE25" for 25% off: https://www.coreimpodcast.com/MKSAP

Transcript & show notes

Tags: CoreIM, IMCore, Gastroenterology, Primary Care, Medical Education, Physician Assistant, Nurse Practitioner, Medical Student, Medical Imaging, Bleeding Assessment, Drain Management, Procedural Sedation

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🔹 High-yield reversible causes of constipation? (02:26)

🔹 Which type of fiber is more helpful? And is more hydration really better? And bulk-forming laxatives (9:03)

🔹 Osmotic vs Stimulant Laxatives (15:06)

🔹 Suppositories and enemas? (25:39)

🔹Best practices with opioid induced constipation (34:05)

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📌 Earn CME credit with ACP for this episode! CME-MOC credit 

📌 Transcript and Show Notes

Tags: CoreIM, IMCore, Gastroenterology, GI Pharmacology, Digestive Health, Primary Care, Medical Education, Physician Assistant, Nurse Practitioner, Medical Student, Laxatives, Stool Softeners, Senna, Bisacodyl, Polyethylene Glycol, Bowel Regimen, Magnesium Citrate, Lactulose

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